Dimethyl Sulfone → 1-(2-Methanesulfonyl-pyridin-4-yl)-ethanone

HRID 1423055Notes

Reaction equation

Br[C:2]1[CH:7]=[C:6]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:4][N:3]=1.[CH3:11][S:12](C)(=[O:14])=[O:13]>>[CH3:11][S:12]([C:2]1[CH:7]=[C:6]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:4][N:3]=1)(=[O:14])=[O:13]

Participants

Reactant 2

HCID 6213Dimethyl Sulfone

HCID 150910131-(2-Bromopyridin-4-yl)ethan-1-one

Product 1

HCID 597885921-(2-Methanesulfonyl-pyridin-4-yl)-ethanone

Procedure

Alternatively, (1-(2-bromopyridin-4-yl)-ethanone) could be converted to the corresponding methyl sulfone via the above procedure to afford 1-(2-methanesulfonyl-pyridin-4-yl)-ethanone. 1-(2-Methanesulfonyl-pyridin-4-yl)-ethanone can be converted to the title compound by methods described in example 14.

Sources & evidence

ORD record: ord-2169fb303b994fc1a143777bb8e4e5b2
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927550B2

Reaction notes

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