Hydrochloric Acid → HCID 70896408, compound

HRID 1423071Notes

Reaction equation

HRID 1423071 reaction equation
C(OC(=O)[NH:7][C:8]1([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([S:17]([CH3:20])(=[O:19])=[O:18])[CH:12]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:22].O1CCOCC1>CO>[ClH:22].[CH3:20][S:17]([C:13]1[CH:12]=[C:11]([C:8]2([NH2:7])[CH2:10][CH2:9]2)[CH:16]=[CH:15][N:14]=1)(=[O:19])=[O:18]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67194852HCID 67194852, compound

Product 1

HCID 70896408HCID 70896408, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of [1-(2-methanesulfonyl-pyridin-4-yl)-cyclopropyl]-carbamic acid tert-butyl ester (606 mg, 1.94 mmol) in methanol (10 mL) is added a solution of 4 N HCl in dioxane (2 mL, 8 mmol). The mixture stirred overnight and is then concentrated and the residue is triturated with ether-ethanol. The solid is collected by filtration to afford the title compound.

Workup

  1. concentrationis then concentrated
  2. customthe residue is triturated with ether-ethanol
  3. filtrationThe solid is collected by filtration

Sources & evidence

ORD record
ord-ed8b51c8556c44b7937ea973c09bc258
Source dataset
uspto-grants-2015_01
Patent number
US08927550B2

Reaction notes

Loading…