5-Bromo-2-methoxyphenol → HCID 66824716, compound

HRID 1423087Notes

Reaction equation

HRID 1423087 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([OH:8])[CH:7]=1.[CH3:11][N:12]1[CH2:16][CH2:15][C@H:14](O)[CH2:13]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([CH:7]=1)[O:8][C@@H:14]1[CH2:15][CH2:16][N:12]([CH3:11])[CH2:13]1

Participants

3

Reactant 2

HCID 1422285-Bromo-2-methoxyphenolHCID 6435041-Methyl-3-pyrrolidinol, (+)-

Product 1

HCID 66824716HCID 66824716, compoundYield 58.4%

Procedure

The title compound was prepared by the method outlined for Preparative Example 63 using 5-bromo-2-methoxy-phenol (1.00 g, 4.926 mmol) and (S)-1-methyl-pyrrolidin-3-ol (601 mg, 5.94 mmol) to afford titled compound as a colorless solid (823 mg, 58%). LC/MS (Method B) 1.18 min, [M+1]+ 286/288.

Workup

  1. customThe title compound was prepared by the method

Sources & evidence

ORD record
ord-b6a201e22a9a4ee88ecc570dc49d4347
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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