1,3-Difluoro-2-propanol → HCID 58189074, compound

HRID 1423089Notes

Reaction equation

HRID 1423089 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([OH:8])[CH:7]=1.[F:11][CH2:12][CH:13](O)[CH2:14][F:15]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([O:8][CH:13]([CH2:14][F:15])[CH2:12][F:11])[CH:7]=1

Participants

3

Reactant 2

HCID 679851,3-Difluoro-2-propanolHCID 1422285-Bromo-2-methoxyphenol

Product 1

HCID 58189074HCID 58189074, compoundYield 56.9%

Procedure

The title compound was prepared by the method outlined for Preparative Example 63 using 5-bromo-2-methoxy-phenol (765 uL, 9.87 mmol) and 1,3-difluoro-2-propanol (765 uL, 9.87 mmol) to afford titled compound as a colorless solid (1.58 g, 55%). 1H NMR (DMSO-d6) 7.28 (d, J=2.4, 1H), 7.14 (dd, J=8.8, 2.4, 1H), 6.97 (d, J=8.8, 1H), 4.55-4.35 (m, 5H), 3.75 (s, 3H). LC/MS (Method B) 3.50 min, [M+1]+ 281/283.

Workup

  1. customThe title compound was prepared by the method

Sources & evidence

ORD record
ord-1e7d55c5b4be4f518c531d783d4a21da
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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