1,3-Difluoro-2-propanol → HCID 58189074, compound

Participants

Reaction Steps

The title compound was prepared by the method outlined for Preparative Example 63 using 5-bromo-2-methoxy-phenol (765 uL, 9.87 mmol) and 1,3-difluoro-2-propanol (765 uL, 9.87 mmol) to afford titled compound as a colorless solid (1.58 g, 55%). 1H NMR (DMSO-d6) 7.28 (d, J=2.4, 1H), 7.14 (dd, J=8.8, 2.4, 1H), 6.97 (d, J=8.8, 1H), 4.55-4.35 (m, 5H), 3.75 (s, 3H). LC/MS (Method B) 3.50 min, [M+1]+ 281/283.

Provenance & Evidence