反应详情

温度

70 °C

A solution of 5-(bromomethyl)-2-methyl-oxazole CAS [82190-68-9] (15 g, 85 mmol) in DMF (150 mL) was treated with NaCN (10.4 g, 213 mmol) at room temperature and the mixture stirred at 70° C. for 1 h. After this time the mixture was poured onto ice-cooled water (300 mL) and extracted with CH2Cl2 (5×200 mL). The combined organic extracts were then washed with brine, dried with Na2SO4 for 30 min, and the mixture concentrated to afford crude 2-methyl-5-oxazoleacetonitrile product CAS [1159511-94-0] (10 g).

1. additionAfter this time the mixture was poured onto ice-
2. extractionextracted with CH2Cl2 (5×200 mL)
3. washThe combined organic extracts were then washed with brine
4. dry with materialdried with Na2SO4 for 30 min
5. concentrationthe mixture concentrated