Hydrochloric Acid → HCID 67291888, compound

Participants

Reaction Steps

The intermediate (S)-2-[(Benzyl-methyl-amino)-methyl]-4-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (300 mg, 0.65 mmol) was then dissolved in 1,4-dioxane (2 mL) and treated with a 4 N solution of hydrogen chloride in 1,4-dioxane (4 mL) and stirred for 6 h. The reaction was then evaporated to afford the title compound as a colorless solid. (180 mg, 99%). LC/MS (Method B) 2.32 min, [M+1]+ 410.

Provenance & Evidence