Hydrochloric Acid → HCID 67291888, compound

HRID 1423105Notes

Reaction equation

HRID 1423105 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:10][C@@H:9]1[CH2:28][N:29]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH3:30])=O)(C)(C)C.[ClH:38]>O1CCOCC1>[ClH:38].[ClH:38].[CH2:31]([N:29]([CH3:30])[CH2:28][C@H:9]1[CH2:10][N:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:12][CH2:13][NH:8]1)[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66824924HCID 66824924, compound

Product 1

HCID 67291888HCID 67291888, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The intermediate (S)-2-[(Benzyl-methyl-amino)-methyl]-4-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (300 mg, 0.65 mmol) was then dissolved in 1,4-dioxane (2 mL) and treated with a 4 N solution of hydrogen chloride in 1,4-dioxane (4 mL) and stirred for 6 h. The reaction was then evaporated to afford the title compound as a colorless solid. (180 mg, 99%). LC/MS (Method B) 2.32 min, [M+1]+ 410.

Workup

  1. customThe reaction was then evaporated

Sources & evidence

ORD record
ord-ccf3669aff16491f974bef593933a5f8
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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