Hydrochloric Acid → (S)-2-amino-1-(2-benzyl-4-(3-(cyclopentyloxy)-4-methoxyphenyl)piperazin-1-yl)ethanone, hydrochloride salt

HRID 1423122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1423122
C(OC(=O)[NH:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)[CH:18]=2)[CH2:13][C@@H:12]1[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:10])(C)(C)C.[ClH:39]>O1CCOCC1>[ClH:39].[NH2:7][CH2:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([O:25][CH:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[CH:18]=2)[CH2:13][C@@H:12]1[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:10]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 66824974{2-[(S)-2-Benzyl-4-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

Produkt 1

HCID 23627688(S)-2-amino-1-(2-benzyl-4-(3-(cyclopentyloxy)-4-methoxyphenyl)piperazin-1-yl)ethanone, hydrochloride saltAusbeute 49 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

The intermediate {2-[(S)-2-Benzyl-4-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester was dissolved in a 4 N solution of hydrogen chloride in dioxane and stirred for 2 h then evaporated to a solid which was filtered and washed with diethyl ether to afford the title compound as a colorless solid (42 mg, 49% based on trihydrochloride salt). LC/MS (Method A) 4.66 min, [M+1]+ 424.

Aufarbeitung

  1. customthen evaporated to a solid which
  2. filtrationwas filtered
  3. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-7525a94b56f247638535f1074e4fb2ce
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08927546B2

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