Hydrochloric Acid → (S)-2-amino-1-(2-benzyl-4-(3-(cyclopentyloxy)-4-methoxyphenyl)piperazin-1-yl)ethanone, hydrochloride salt

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The intermediate {2-[(S)-2-Benzyl-4-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester was dissolved in a 4 N solution of hydrogen chloride in dioxane and stirred for 2 h then evaporated to a solid which was filtered and washed with diethyl ether to afford the title compound as a colorless solid (42 mg, 49% based on trihydrochloride salt). LC/MS (Method A) 4.66 min, [M+1]+ 424.

Provenance & Evidence