Ethylamine → HCID 52918527, compound

HRID 1423133Notes

Reaction equation

HRID 1423133 reaction equation
C(O[C:4](=[O:35])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]3[C:13]=2[CH:14]=[CH:15][C:16]([C:24]([F:27])([F:26])[F:25])=[N:17]3)[CH2:8][C@@H:7]1[CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)C.[CH2:36]([NH2:38])[CH3:37]>C1COCC1>[CH2:28]([C@H:7]1[CH2:8][N:9]([C:12]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]3[C:13]=2[CH:14]=[CH:15][C:16]([C:24]([F:26])([F:25])[F:27])=[N:17]3)[CH2:10][CH2:11][N:6]1[CH2:5][C:4]([NH:38][CH2:36][CH3:37])=[O:35])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 66824790HCID 66824790, compound

Product 1

HCID 52918527HCID 52918527, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by the method outlined for Example 117 using [(S)-2-Benz yl-4-(8-methoxy-2-trifluoromethyl-quinolin-5-yl)-piperazin-1-yl]-acetic acid ethyl ester and a 2 M THF solution of ethylamine. The title compound was isolated as a yellow solid (68 mg, 63%). LC/MS (Method B) 2.82 min, [M+1]+ 486.

Workup

  1. customThe title compound was prepared by the method

Sources & evidence

ORD record
ord-e59ff2f7d8d3433abfb21e49713ea8e5
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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