Imidazole-4-acetic acid → HCID 178491981, compound

HRID 1423176Notes

Reaction equation

HRID 1423176 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]([OH:9])=O)[N:3]=[CH:2]1.[CH2:10]([C@@H:17]1[NH:22][CH2:21][CH2:20][N:19]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH:32]([F:34])[F:33])[CH:24]=2)[CH2:18]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([C@H:17]1[CH2:18][N:19]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH:32]([F:34])[F:33])[CH:24]=2)[CH2:20][CH2:21][N:22]1[C:7](=[O:9])[CH2:6][C:4]1[N:3]=[CH:2][NH:1][CH:5]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 96215Imidazole-4-acetic acidHCID 52920372(S)-3-benzyl-1-(3-(difluoromethoxy)-4-methoxyphenyl)piperazine2×

Product 1

HCID 178491981HCID 178491981, compound

Procedure

Prepared by the method outlined for Example 189 using (1H-imidazol-4-yl)-acetic acid and (S)3-benzyl-1-(3-difluoromethoxy-4-methoxy-phenyl)-piperazine (Example 69, Compound 157) as starting materials. Product as an oil. LC/MS (Method B) 3.14 min, [M+1]+ 457. Potency class C.

Workup

  1. customPrepared by the method
  2. customLC/MS (Method B) 3.14 min, [M+1]+ 457

Sources & evidence

ORD record
ord-34e5aee55e8f4023be2a3226e39e90d2
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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