N-(tert-butoxycarbonyl)glycine → HCID 58189205, compound

HRID 1423177Notes

Reaction equation

HRID 1423177 reaction equation
C(OC([NH:8][CH2:9][C:10](O)=[O:11])=O)(C)(C)C.[CH2:13]([C@@H:20]1[NH:25][CH2:24][CH2:23][N:22]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([O:34][CH:35]3[CH2:38][CH2:37][CH2:36]3)[CH:27]=2)[CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[NH2:8][CH2:9][C:10]([N:25]1[CH2:24][CH2:23][N:22]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([O:34][CH:35]3[CH2:38][CH2:37][CH2:36]3)[CH:27]=2)[CH2:21][C@@H:20]1[CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:11]

Participants

3

Reactant 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 58188985HCID 58188985, compound2×

Product 1

HCID 58189205HCID 58189205, compound

Procedure

Prepared by the method outlined for Example 91 using tert-butoxycarbonylamino acetic acid and (S)3-benzyl-1-(3-cyclobutoxy-4-methoxy-phenyl)-piperazine (Example 7, Compound 95) as staring materials to afford product as an oil. LC/MS (Method B) 3.55 min, [M+1]+ 410. Potency class C.

Workup

  1. customPrepared by the method
  2. customto afford product as an oil
  3. customLC/MS (Method B) 3.55 min, [M+1]+ 410

Sources & evidence

ORD record
ord-c2e3cb31cab64180856b46eb26f2c84f
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

Loading…