Imidazole-4-acetic acid → HCID 178445828, compound

HRID 1423186Notes

Reaction equation

HRID 1423186 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]([OH:9])=O)[N:3]=[CH:2]1.[CH:10]1([CH2:13][O:14][C:15]2[CH:16]=[C:17]([N:25]3[CH2:30][CH2:29][NH:28][C@@H:27]([CH2:31][CH:32]([CH3:34])[CH3:33])[CH2:26]3)[CH:18]=[CH:19][C:20]=2[O:21][CH:22]([F:24])[F:23])[CH2:12][CH2:11]1>>[CH:10]1([CH2:13][O:14][C:15]2[CH:16]=[C:17]([N:25]3[CH2:30][CH2:29][N:28]([C:7](=[O:9])[CH2:6][C:4]4[N:3]=[CH:2][NH:1][CH:5]=4)[C@@H:27]([CH2:31][CH:32]([CH3:34])[CH3:33])[CH2:26]3)[CH:18]=[CH:19][C:20]=2[O:21][CH:22]([F:23])[F:24])[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 96215Imidazole-4-acetic acidHCID 58189099HCID 58189099, compound2×

Product 1

HCID 178445828HCID 178445828, compound

Procedure

Prepared by the method outlined for Example 189 using 2-(1H-imidazol-4-yl)acetic acid and (S)-1-(3-cyclopropylmethoxy-4-difluoromethoxy-phenyl)-3-isobutyl-piperazine (Example 37, Compound 125) as starting materials. Product as an off-white solid (14%). LC/MS (Method B) 2.94 min, [M+1]+ 463.0. Potency class B.

Workup

  1. customPrepared by the method
  2. customLC/MS (Method B) 2.94 min, [M+1]+ 463.0

Sources & evidence

ORD record
ord-3736f7ca8cf140a8849bdfc9fe2bf56c
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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