2-(3-methyl-1H-1,2,4-triazol-5-yl)acetic acid → HCID 178491987, compound

HRID 1423233Notes

Reaction equation

HRID 1423233 reaction equation
Cl.Cl.[CH2:3]([C@@H:10]1[NH:15][CH2:14][CH2:13][N:12]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH:25]3[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]3)[CH:17]=2)[CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:32][C:33]1[NH:37][N:36]=[C:35]([CH2:38][C:39](O)=[O:40])[N:34]=1>>[CH2:3]([C@H:10]1[CH2:11][N:12]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH:25]3[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]3)[CH:17]=2)[CH2:13][CH2:14][N:15]1[C:39](=[O:40])[CH2:38][C:35]1[NH:34][C:33]([CH3:32])=[N:37][N:36]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 70194772-(3-methyl-1H-1,2,4-triazol-5-yl)acetic acidHCID 66825019(S)-3-benzyl-1-[4-methoxy-3-(1-methyl-piperidin-4-yloxy)-phenyl]-piperazine dihydrochloride

Product 1

HCID 178491987HCID 178491987, compoundYield 17%

Procedure

Prepared using the same procedure described in Example 189 from (S)-3-benzyl-1-[4-methoxy-3-(1-methyl-piperidin-4-yloxy)-phenyl]-piperazine dihydrochloride and (5-methyl-1H-[1,2,4]triazol-3-yl)-acetic acid to afford the title compound as colorless solid (20 mg, 17%). LC/MS (Method B) 2.10 min, [M+1]+ 519.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-82e037da24514ddf81391a16f959f342
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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