2-(3-methyl-1H-1,2,4-triazol-5-yl)acetic acid → HCID 178491985, compound

HRID 1423237Notes

Reaction equation

HRID 1423237 reaction equation
[CH2:1]([C@@H:8]1[NH:13][CH2:12][CH2:11][N:10]([C:14]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]3[C:15]=2[CH:16]=[CH:17][C:18]([C:26]([F:29])([F:28])[F:27])=[N:19]3)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:30][C:31]1[NH:35][N:34]=[C:33]([CH2:36][C:37](O)=[O:38])[N:32]=1>>[CH2:1]([C@H:8]1[CH2:9][N:10]([C:14]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]3[C:15]=2[CH:16]=[CH:17][C:18]([C:26]([F:29])([F:27])[F:28])=[N:19]3)[CH2:11][CH2:12][N:13]1[C:37](=[O:38])[CH2:36][C:33]1[NH:34][N:35]=[C:31]([CH3:30])[N:32]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 70194772-(3-methyl-1H-1,2,4-triazol-5-yl)acetic acidHCID 58188941(S)-5-(3-benzylpiperazin-1-yl)-8-methoxy-2-(trifluoromethyl)quinoline

Product 1

HCID 178491985HCID 178491985, compoundYield 12%

Procedure

Prepared using the same procedure described in Example 189 from 5-((S)-3-benzyl-piperazin-1-yl)-8-methoxy-2-trifluoromethyl-quinoline and (5-methyl-1H-[1,2,4]triazol-3-yl)-acetic acid to afford the title compound as colorless solid (17 mg, 12%). LC/MS (Method B) 3.22 min, [M+1]+ 525.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-eadb0889cffd42c6a1c427775c1132b5
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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