2-Bromopropane → HCID 58189236, compound

HRID 1423250Notes

Reaction equation

HRID 1423250 reaction equation
[CH2:1]([C@H:8]1[CH2:13][N:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:11][CH2:10][N:9]1[C:28](=[O:35])[CH2:29][C:30]1[N:31]=[CH:32][NH:33][CH:34]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH:37]([CH3:39])[CH3:38]>>[CH2:1]([C@H:8]1[CH2:13][N:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH:15]=2)[CH2:11][CH2:10][N:9]1[C:28](=[O:35])[CH2:29][C:30]1[N:31]=[CH:32][N:33]([CH:37]([CH3:39])[CH3:38])[CH:34]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 63582-BromopropaneHCID 178491980HCID 178491980, compound

Product 1

HCID 58189236HCID 58189236, compoundYield 20%

Procedure

Prepared using the same procedure described in Example 336 using 1-[(S)-2-benzyl-4-(3-cyclopentyloxy-4-methoxy-phenyl)-piperazin-1-yl]-2-(1H-imidazol-4-yl)-ethanone and 2-bromopropane to afford the title compound as an orange solid (67 mg, 20% overall). LC/MS (Method B) 2.88 min, [M+1]+ 517.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-339e6bffc8b54ef5aaefe9500228e530
Source dataset
uspto-grants-2015_01
Patent number
US08927546B2

Reaction notes

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