反应详情

To a stirred solution of the product from step (v) above (540 mg, 0.825 mmol) in DCM (8 mL) was added TFA (3.2 mL, 41.5 mmol). The reaction was stirred at it for 1 h. The solution was concentrated in vacuo and the resulting oil dissolved in the minimum of MeOH and loaded onto SCX. The column was eluted with MeOH (3 column volumes), then 1% NH3 in MeOH (3 column volumes). The product-containing portion was concentrated in vacuo to afford the sub-title compound (405 mg) as a light, brown foam.

1. concentrationThe solution was concentrated in vacuo
2. dissolutionthe resulting oil dissolved in the minimum of MeOH
3. washThe column was eluted with MeOH (3 column volumes)
4. concentrationThe product-containing portion was concentrated in vacuo