isopropyl 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxy-benzoate → 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoic acid

Participants

Reaction Steps

A solution of isopropyl 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoate (0.720 g, 2.4 mmol) in 2N hydrochloric acid (10 ml) was heated to 100° C. for 10 hours. The solvent was removed under reduced pressure to give 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoic acid (HCl salt) as a brown powder. (0.715 g, 2.4 mmol). 100% yield. 259 (M+1).

Provenance & Evidence