isopropyl 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxy-benzoate → 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoic acid

HRID 1423337Notes

Reaction equation

HRID 1423337 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][N:7]([C:9]3[CH:10]=[CH:11][C:12]([O:21][CH3:22])=[C:13]([CH:20]=3)[C:14]([O:16]C(C)C)=[O:15])[CH:8]=2)[CH2:3][CH2:2]1>Cl>[CH:1]1([C:4]2[N:5]=[CH:6][N:7]([C:9]3[CH:10]=[CH:11][C:12]([O:21][CH3:22])=[C:13]([CH:20]=3)[C:14]([OH:16])=[O:15])[CH:8]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 1

HCID 58035659isopropyl 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxy-benzoate

Product 1

HCID 580356325-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoic acidYield 100%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of isopropyl 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoate (0.720 g, 2.4 mmol) in 2N hydrochloric acid (10 ml) was heated to 100° C. for 10 hours. The solvent was removed under reduced pressure to give 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoic acid (HCl salt) as a brown powder. (0.715 g, 2.4 mmol). 100% yield. 259 (M+1).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-7ea49d58377e4ea68d6a375368dbe1ff
Source dataset
uspto-grants-2015_01
Patent number
US08927582B2

Reaction notes

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