反应详情

温度

100 °C

A solution of ethyl 4-methyl-3-(2-nitrophenyl)-1H-pyrrole-2-carboxylate (3.2 g, 11.67 mmol) in AcOH (117 mL) was treated at 20° C. with iron dust (6.52 g, 117 mmol). The reaction mixture was heated at 100° C. for 3 h. The white precipitate was removed by filtration and the filtrates were concentrated to give a residue that was purified on silica gel (gradient elution, 50-100% MeOH/Acetone) to afford the title compound (2.0 g, 86%) as a solid. LCMS (ES+) m/z 199 (M+H)+.

1. customThe white precipitate was removed by filtration
2. concentrationthe filtrates were concentrated
3. customto give a residue that
4. customwas purified on silica gel (gradient elution, 50-100% MeOH/Acetone)