反应详情

A reaction flask, equipped with a mechanic stirrer, a reflux condenser and a nitrogen bubbler is charged with POCl3 (1200 mL). Ethyl 4-hydroxy-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate from example A3 (207.19 g; 1.00 mol) is added in several portions. The carefully stirred suspension is heated to gentle reflux for five hours.

1. customA reaction flask, equipped with a mechanic stirrer, a reflux condenser
2. temperatureThe carefully stirred suspension is heated
3. temperatureto gentle reflux for five hours