Bromomethylcyclopropane → 1-[3-Bromo-4-(cyclopropylmethoxy)phenyl]ethanone

HRID 1423402Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[OH:8].Br[CH2:13][CH:14]1[CH2:16][CH2:15]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[O:8][CH2:13][CH:14]1[CH2:16][CH2:15]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 6080941-(3-Bromo-4-hydroxyphenyl)ethanone

Product 1

HCID 629080041-[3-Bromo-4-(cyclopropylmethoxy)phenyl]ethanone

Procedure

Starting from 1-(3-bromo-4-hydroxy-phenyl)-ethanone (example B.a4) and commercially available bromomethyl-cyclopropane the title compound is obtained as colorless solid.

Sources & evidence

ORD record: ord-574e6d9248d7430ba1e3226e71ba8071
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927557B2

Reaction notes

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