Propan-2-one--water (1/1) → (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride monohydrate

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Reaction Steps

60.5 mg of amorphous (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride was dissolved in 0.3 mL isopropanol/t-butyl methyl ether (7:3 ratio by volume) and 2.0 mL acetone/water (19:1 ratio by volume) mixed solvent system at room temperature. The container was left open, and the crystals that had formed were collected. The crystalline solid was dried at 40-50° C. under vacuum to give crystalline (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride monohydrate.

Provenance & Evidence