(4-Methoxyphenyl)boronic acid → HCID 178498915, compound

HRID 1423943Notes

Reaction equation

HRID 1423943 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][C:11](Br)=[CH:10][CH:9]=2)=[O:4].[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][C:11]([C:23]1[CH:24]=[CH:25][C:20]([O:19][CH3:18])=[CH:21][CH:22]=1)=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 178498908HCID 178498908, compound

Product 1

HCID 178498915HCID 178498915, compound

Procedure

4-Hydroxy-6-(4-methoxy-phenyl)-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 6-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester under conditions analogous to Example 7(a) using 4-methoxy-phenylboronic acid. 1H NMR (200 MHz, CDCl3): δ (ppm)=8.521 (s, 1H), 7.803-7.352 (m, 5H), 7.001 (s, 1H), 4.022 (s, 3H), 3.864 (s, 3H).

Sources & evidence

ORD record
ord-7f939571d5604dbca45e6eb999c0fbce
Source dataset
uspto-grants-2015_01
Patent number
US08927591B2

Reaction notes

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