4-Fluorophenylboronic acid → HCID 178498913, compound

HRID 1423946Notes

Reaction equation

HRID 1423946 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][C:11](Br)=[CH:10][CH:9]=2)=[O:4].[F:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][C:11]([C:22]1[CH:23]=[CH:24][C:19]([F:18])=[CH:20][CH:21]=1)=[CH:10][CH:9]=2)=[O:4]

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 178498908HCID 178498908, compound

Product 1

HCID 178498913HCID 178498913, compound

Procedure

6-(4-Fluoro-phenyl)-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 6-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester under conditions analogous to Example 7(a) using 4-fluoro-phenylboronic acid. 1H NMR (200 MHz, CDCl3): δ (ppm)=8.515 (s, 1H), 7.765 (d, 1H), 7.586 (m, 2H), 7.427 (d, 1H), 7.381-7.120 (m, 2H), 4.026 (s, 3H).

Sources & evidence

ORD record
ord-8b2156c583a04690a9929c0f14b2d10c
Source dataset
uspto-grants-2015_01
Patent number
US08927591B2

Reaction notes

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