Cyclopropylboronic acid → HCID 178498917, compound

HRID 1423957Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10](Br)[CH:9]=2)=[O:4].[CH:18]1(B(O)O)[CH2:20][CH2:19]1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([CH:18]1[CH2:20][CH2:19]1)[CH:9]=2)=[O:4]

Participants

Reactant 2

HCID 2760897Cyclopropylboronic acid

HCID 178498916HCID 178498916, compound

Product 1

HCID 178498917HCID 178498917, compound

Procedure

7-Cyclopropyl-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 7-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester under conditions analogous to Example 7(a) using cyclopropylboronic acid. The crude material was used in the next step without purification.

Workup

customThe crude material was used in the next step without purification

Sources & evidence

ORD record: ord-28f8611f3b044b508928fb91f3560306
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927591B2

Reaction notes

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