反应详情

A mixed solution of the compound (200 mg, 0.458 mmol) obtained in Example 65 and potassium hydroxide (129 mg) in ethanol (5.00 mL) and water (1.50 mL) was stirred at 100° C. for 9 h. The reaction mixture was cooled to room temperature, poured into 0.05 N hydrochloric acid (50.0 mL) with ice cooling, extracted with dichloromethane/2-propanol (4/1), and dried with anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. Diisopropyl ether was added to the residue, and the white precipitate was collected by filtration and dried under reduced pressure to obtain the title compound (166 mg, 83%) as a white solid.

1. extractionextracted with dichloromethane/2-propanol (4/1)
2. dry with materialdried with anhydrous sodium sulfate
3. distillationthe solvent was distilled off under reduced pressure
4. additionDiisopropyl ether was added to the residue
5. filtrationthe white precipitate was collected by filtration
6. customdried under reduced pressure