4-Tert-butylbenzene-1,2-diamine → HCID 178496738, compound

HRID 1424148Notes

Reaction equation

HRID 1424148 reaction equation
C(OC([NH:8][C@@H:9]([C:14](O)=O)[C@H:10]([CH3:13])[O:11][CH3:12])=O)(C)(C)C.[C:17]([C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[C:23]([NH2:28])[CH:22]=1)([CH3:20])([CH3:19])[CH3:18]>>[C:17]([C:21]1[CH:26]=[CH:25][C:24]2[NH:27][C:14]([C@H:9]([NH2:8])[C@@H:10]([O:11][CH3:12])[CH3:13])=[N:28][C:23]=2[CH:22]=1)([CH3:20])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 4327084-Tert-butylbenzene-1,2-diamineHCID 23540191(2R,3S)-2-{[(tert-butoxy)carbonyl]amino}-3-methoxybutanoic acid

Product 1

HCID 178496738HCID 178496738, compound

Procedure

The title compound was prepared according to Method 1 using N-(tert-butoxycarbonyl)-O-methyl-D-threonine and 4-tert-butyl-1,2-diaminobenzene. The residue was purified by elution through an SCX cartridge with MeOH followed by 2M NH3 in MeOH followed by silica gel column chromatography eluting with 90:10:1 DCM:MeOH:NH3.

Workup

  1. customThe residue was purified by elution through an SCX cartridge with MeOH
  2. washeluting with 90:10:1 DCM

Sources & evidence

ORD record
ord-7b00e4e0eec146989f0089a4a0487db3
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

Loading…