143364-85-6 → HCID 86699060, compound

HRID 1424160Notes

Reaction equation

HRID 1424160 reaction equation
C(OC([N:8]1[C@H:12]([C:13](O)=O)[C@@H:11]([CH3:16])[O:10]C1(C)C)=O)(C)(C)C.[NH2:19][C:20]1[C:21]([Cl:36])=[C:22]([C:27]2[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[C:29]([F:35])[CH:28]=2)[CH:23]=[CH:24][C:25]=1[NH2:26]>>[NH2:8][C@H:12]([C:13]1[NH:26][C:25]2[CH:24]=[CH:23][C:22]([C:27]3[CH:32]=[CH:31][C:30]([C:33]#[N:34])=[C:29]([F:35])[CH:28]=3)=[C:21]([Cl:36])[C:20]=2[N:19]=1)[C@H:11]([OH:10])[CH3:16]

Participants

3

Reactant 2

HCID 10956272143364-85-6HCID 86699061HCID 86699061, compound

Product 1

HCID 86699060HCID 86699060, compound

Procedure

The title compound was prepared according to Method 4 using (4S,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid (Preparation 57) and 3′,4′-diamino-2′-chloro-3-fluorobiphenyl-4-carbonitrile (Preparation 80). The final residue was purified using silica gel column chromatography eluting with DCM:MeOH (7N NH3), 97:3 to 93:7 and freeze dried for 18 hours.

Workup

  1. customThe final residue was purified
  2. washeluting with DCM
  3. dry with materialMeOH (7N NH3), 97:3 to 93:7 and freeze dried for 18 hours

Sources & evidence

ORD record
ord-ca5e8e92a63a45cc83a78ac331c27e0b
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

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