HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4S,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyloxazolidine-4-carboxylic acid → HCID 86699060, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4S,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyloxazolidine-4-carboxylic acid | HCID 10956272 | — |
| Reactant | HCID 86699061 | HCID 86699061 | — |
| Product | HCID 86699060 | HCID 86699060 | — |
Reaction Steps
The title compound was prepared according to Method 4 using (4S,5R)-3-(tert-butoxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid (Preparation 57) and 3′,4′-diamino-2′-chloro-3-fluorobiphenyl-4-carbonitrile (Preparation 80). The final residue was purified using silica gel column chromatography eluting with DCM:MeOH (7N NH3), 97:3 to 93:7 and freeze dried for 18 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927587B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-ca5e8e92a63a45cc83a78ac331c27e0b |
| Source note | uspto-grants-2015_01 |