4-Tert-butylbenzene-1,2-diamine → HCID 178440689, compound

HRID 1424166Notes

Reaction equation

HRID 1424166 reaction equation
C([N:8]1[CH2:15][C@@H:14]([F:16])[CH2:13][C@H:9]1[C:10](O)=O)(OC(C)(C)C)=O.[C:17]([C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[C:23]([NH2:28])[CH:22]=1)([CH3:20])([CH3:19])[CH3:18]>>[C:17]([C:21]1[CH:26]=[CH:25][C:24]2[NH:27][C:10]([C@@H:9]3[CH2:13][C@H:14]([F:16])[CH2:15][NH:8]3)=[N:28][C:23]=2[CH:22]=1)([CH3:20])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 4327084-Tert-butylbenzene-1,2-diamineHCID 2756017(4S)-1-tert-Butoxycarbonyl-4-fluoro-L-proline

Product 1

HCID 178440689HCID 178440689, compound

Procedure

The title compound was prepared according to Method 4 using N-Boc-cis-4-fluoro-L-proline and 4-tert-butyl-1,2-diaminobenzene. The final residue was washed with ethyl acetate and diluted with water, basified with saturated lithium hydroxide solution (pH=8), extracted with ethyl acetate and dried over anhydrous Na2SO4 and concentrated under reduced pressure.

Workup

  1. washThe final residue was washed with ethyl acetate
  2. additiondiluted with water
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over anhydrous Na2SO4
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-a8394b0e07a44f0b87b4557d1e35e1d2
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

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