4-Tert-butylbenzene-1,2-diamine → HCID 178448390, compound

HRID 1424167Notes

Reaction equation

HRID 1424167 reaction equation
C(OC([N:8]1[C@H:12]([C:13](O)=O)[C@@H:11]([CH:16]([CH3:18])[CH3:17])[O:10]C1(C)C)=O)(C)(C)C.[C:21]([C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[C:27]([NH2:32])[CH:26]=1)([CH3:24])([CH3:23])[CH3:22]>>[NH2:8][C@H:12]([C:13]1[NH:31][C:28]2[CH:29]=[CH:30][C:25]([C:21]([CH3:24])([CH3:22])[CH3:23])=[CH:26][C:27]=2[N:32]=1)[C@H:11]([OH:10])[CH:16]([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 4327084-Tert-butylbenzene-1,2-diamineHCID 70021709(4S,5R)-3-(tert-butoxycarbonyl)-5-isopropyl-2,2-dimethyl-1,3-oxazolidine-4-carboxylic acid

Product 1

HCID 178448390HCID 178448390, compound

Procedure

The title compound was prepared according to Method 4 using (4S,5R)-3-(tert-butoxycarbonyl)-5-isopropyl-2,2-dimethyl-1,3-oxazolidine-4-carboxylic acid (Preparation 60) and 4-tert-butyl-1,2-diaminobenzene. The final residue was washed with ethyl acetate and diluted with water, basified with saturated lithium hydroxide solution (pH=8), extracted with ethyl acetate and dried over anhydrous Na2SO4 and concentrated under reduced pressure.

Workup

  1. washThe final residue was washed with ethyl acetate
  2. additiondiluted with water
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over anhydrous Na2SO4
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b65348be721948d2bb5259f774e03614
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

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