huagongshe.com
HRID1424170

反应详情

EQUATION

反应方程式

HRID 1424170 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)c1ccc(N)c(N)c1
HCID432708

4-(TERT-BUTYL)BENZENE-1,2-DIAMINE

C10H16N2

结构：CC(=O)O[C@@H]1CCN(C(=O)OC(C)(C)C)[C@@H]1C(=O)O
HCID86699073

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)c1ccc2[nH]c([C@H]3NCC[C@H]3O)nc2c1
HCID178440690

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cl
溶剂HCID313

Hydrochloric Acid

ClH

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

The title compound was prepared according to Method 4 Steps 1 and 2 using (3R)-3-acetoxy-1-(tert-butoxycarbonyl)-L-proline (Preparation 47) and 4-tert-butyl-1,2-diaminobenzene. The residue was dissolved in 6N HCl (5 mL) at 0° C. and then heated to 60° C. for 4 hours. The reaction was cooled, concentrated in vacuo and purified through an SCX cartridge (47 mg, 66%).

WORKUP

后处理

  1. temperatureThe reaction was cooled
  2. concentrationconcentrated in vacuo
  3. custompurified through an SCX cartridge (47 mg, 66%)