HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propylphosphonic anhydride → HCID 178495065, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propylphosphonic anhydride | HCID 111923 | — |
| Reactant | 2-(((Tert-butoxy)carbonyl)amino)-3-methoxy-3-methylbutanoic acid | HCID 23138410 | — |
| Reactant | HCID 86699023 | HCID 86699023 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 178495065 | HCID 178495065 | — |
Reaction Steps
The title compound was prepared according to Method 4 using T3P and triethylamine in the first step with 2-{[(tert-butoxy)carbonyl]amino}-3-methoxy-3-methylbutanoic acid and 3′,4′-diaminobiphenyl-4-carbonitrile (Preparation 82). The reaction was concentrated to dryness, triturated with ether and purified using preparative HPLC. Rt=3.21 minutes MS m/z 321 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927587B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-f38b77baf4f549e9ac3ec452783b8011 |
| Source note | uspto-grants-2015_01 |