Propylphosphonic anhydride → HCID 178495065, compound

HRID 1424175Notes

Reaction equation

HRID 1424175 reaction equation
C(P1(=O)OP(CCC)(=O)OP(CCC)(=O)O1)CC.C(OC([NH:26][CH:27]([C:31]([O:34][CH3:35])([CH3:33])[CH3:32])[C:28](O)=O)=O)(C)(C)C.[NH2:36][C:37]1[CH:38]=[C:39]([C:44]2[CH:49]=[CH:48][C:47]([C:50]#[N:51])=[CH:46][CH:45]=2)[CH:40]=[CH:41][C:42]=1[NH2:43]>C(N(CC)CC)C>[NH2:26][CH:27]([C:28]1[NH:43][C:42]2[CH:41]=[CH:40][C:39]([C:44]3[CH:45]=[CH:46][C:47]([C:50]#[N:51])=[CH:48][CH:49]=3)=[CH:38][C:37]=2[N:36]=1)[C:31]([O:34][CH3:35])([CH3:32])[CH3:33]

Participants

5

Reactant 3

HCID 111923Propylphosphonic anhydrideHCID 231384102-(((Tert-butoxy)carbonyl)amino)-3-methoxy-3-methylbutanoic acidHCID 86699023HCID 86699023, compound

Product 1

HCID 178495065HCID 178495065, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was prepared according to Method 4 using T3P and triethylamine in the first step with 2-{[(tert-butoxy)carbonyl]amino}-3-methoxy-3-methylbutanoic acid and 3′,4′-diaminobiphenyl-4-carbonitrile (Preparation 82). The reaction was concentrated to dryness, triturated with ether and purified using preparative HPLC. Rt=3.21 minutes MS m/z 321 [M+H]+

Workup

  1. concentrationThe reaction was concentrated to dryness
  2. customtriturated with ether
  3. custompurified

Sources & evidence

ORD record
ord-f38b77baf4f549e9ac3ec452783b8011
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

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