4-Tert-butylbenzene-1,2-diamine → HCID 178454207, compound

HRID 1424201Notes

Reaction equation

HRID 1424201 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][C@@H:12]([C:21](O)=O)[NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:24]([C:28]1[CH:33]=[CH:32][C:31]([NH2:34])=[C:30]([NH2:35])[CH:29]=1)([CH3:27])([CH3:26])[CH3:25]>>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][C@H:12]([NH:13][C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[C:21]1[NH:34][C:31]2[CH:32]=[CH:33][C:28]([C:24]([CH3:27])([CH3:26])[CH3:25])=[CH:29][C:30]=2[N:35]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 4327084-Tert-butylbenzene-1,2-diamineHCID 10687368HCID 10687368, compound

Product 1

HCID 178454207HCID 178454207, compound

Procedure

The title compound was prepared according to Method 4 Steps 1 and 2 using 5-(benzyloxy)-N-(tert-butoxycarbonyl)-L-norvaline and 4-tert-butyl-1,2-diaminobenzene. The crude product was purified by silica gel column chromatography eluting with 30-40% EtOAc in petroleum ether (430 mg, 52%).

Workup

  1. customThe crude product was purified by silica gel column chromatography
  2. washeluting with 30-40% EtOAc in petroleum ether (430 mg, 52%)

Sources & evidence

ORD record
ord-b24118d173c2439fa7a485ce5edc273d
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

Loading…