HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → (3R,4S)-4-(6-(tert-butyl)imidazo[1,2-a]pyridin-2-yl)-3-methylazetidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | (3R,4S)-4-(6-(tert-butyl)imidazo[1,2-a]pyridin-2-yl)-1-(tert-butyldimethylsilyl)-3-methylazetidin-2-one | HCID 86699118 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (3R,4S)-4-(6-(tert-butyl)imidazo[1,2-a]pyridin-2-yl)-3-methylazetidin-2-one | HCID 86699117 | — |
Reaction Steps
(3R,4S)-4-(6-(tert-butyl)imidazo[1,2-a]pyridin-2-yl)-1-(tert-butyldimethylsilyl)-3-methylazetidin-2-one (Preparation 40) was dissolved in THF and 1 M tetrabutylammonium fluoride in THF (3 mL, 10 mmol) was added. The reaction mixture was stirred for 2 hours then the solvent was removed in vacuo. The intermediate was purified by silica gel column chromatography eluting with 0-100% CMA80 in dichloromethane to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927587B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-49eedb815f404ac2a2f309eb496b9ad7 |
| Source note | uspto-grants-2015_01 |