反应详情

温度

140 °C

A mixture of 4-bromo-5-fluorobenzene-1,2-diamine (82.1 mg, 0.400 mmol), [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (20.2 mg, 0.0276 mmol), and neopentylzinc bromide in tetrahydrofuran (0.5 M, 3.0 mL, 1.5 mmol) was degassed for 5 minutes using argon. The reaction mixture was heated under microwave irradiation for 5 minutes at 140° C. The solution was concentrated in vacuo and purified by silica gel column chromatography eluting with 0-100% ethyl acetate/hexanes to afford the title compound (22 mg, 28%) as an orange oil.

1. customwas degassed for 5 minutes
2. concentrationThe solution was concentrated in vacuo
3. custompurified by silica gel column chromatography
4. washeluting with 0-100% ethyl acetate/hexanes