HCID 86699133, compound → HCID 86699061, compound

Participants

Reaction Steps

To a cooled solution (0° C.) of zinc dust (9.34 g, 143 mmol) in AcOH (33 mL), THF (33 mL) and water (9.5 mL) was added 4′-amino-2′-chloro-3-fluoro-3′-nitrobiphenyl-4-carbonitrile (Preparation 93, 2.6 g, 8.93 mmol) and the reaction was allowed to warm to room temperature for 1 hour before filtering through arbocel. The filtrate was diluted with water (200 mL) and EtOAc (200 mL) and the organic layer was collected, dried over MgSO4 and concentrated in vacuo to afford the title compound (2.41 g, quant).

Provenance & Evidence