反应详情

To a cooled solution (0° C.) of zinc dust (9.34 g, 143 mmol) in AcOH (33 mL), THF (33 mL) and water (9.5 mL) was added 4′-amino-2′-chloro-3-fluoro-3′-nitrobiphenyl-4-carbonitrile (Preparation 93, 2.6 g, 8.93 mmol) and the reaction was allowed to warm to room temperature for 1 hour before filtering through arbocel. The filtrate was diluted with water (200 mL) and EtOAc (200 mL) and the organic layer was collected, dried over MgSO4 and concentrated in vacuo to afford the title compound (2.41 g, quant).

1. filtrationbefore filtering through arbocel
2. additionThe filtrate was diluted with water (200 mL) and EtOAc (200 mL)
3. customthe organic layer was collected
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo