(4-Cyano-3-fluorophenyl)boronic acid → HCID 86699133, compound

HRID 1424230Notes

Reaction equation

HRID 1424230 reaction equation
[F:1][C:2]1[CH:3]=[C:4](B(O)O)[CH:5]=[CH:6][C:7]=1[C:8]#[N:9].Br[C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[C:16]([N+:21]([O-:23])=[O:22])[C:15]=1[Cl:24]>>[NH2:18][C:17]1[CH:19]=[CH:20][C:14]([C:4]2[CH:5]=[CH:6][C:7]([C:8]#[N:9])=[C:2]([F:1])[CH:3]=2)=[C:15]([Cl:24])[C:16]=1[N+:21]([O-:23])=[O:22]

Participants

3

Reactant 2

HCID 2783130(4-Cyano-3-fluorophenyl)boronic acidHCID 265991564-Bromo-3-chloro-2-nitroaniline

Product 1

HCID 86699133HCID 86699133, compound

Procedure

The title compound was prepared according to Preparation 92 using 3-fluoro-4-cyanophenylboronic acid and 4-bromo-3-chloro-2-nitroaniline. The residue was purified using silica gel column chromatography eluting with 10-50% EtOAc in heptanes to afford a yellow solid (2.45 g, 52%).

Workup

  1. customThe residue was purified
  2. washeluting with 10-50% EtOAc in heptanes

Sources & evidence

ORD record
ord-b5ef646abe7e4faaa8c16e3e56b8f233
Source dataset
uspto-grants-2015_01
Patent number
US08927587B2

Reaction notes

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