Trifluoroacetic acid → N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide

HRID 1424525노트

반응식

HRID 1424525 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]1[O:15][CH:14]=[N:13][CH:12]=1)[C:5]([OH:7])=O.C(OC([N:23]1[CH2:28][CH2:27][CH:26]([NH:29][CH:30]2[CH2:32][CH2:31]2)[CH2:25][CH2:24]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH:30]1([N:29]([CH:26]2[CH2:27][CH2:28][NH:23][CH2:24][CH2:25]2)[C:5](=[O:7])[C:4]2[CH:8]=[CH:9][C:10]([C:11]3[O:15][CH:14]=[N:13][CH:12]=3)=[C:2]([F:1])[CH:3]=2)[CH2:32][CH2:31]1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 2769591tert-Butyl 4-(cyclopropylamino)piperidine-1-carboxylateHCID 682901443-Fluoro-4-oxazol-5-yl-benzoic acid

생성물 1

HCID 68290215N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound is prepared from 3-fluoro-4-oxazol-5-yl-benzoic acid and 4-cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester following a procedure analogous to that described for Intermediate 1. The deprotection step is accomplished by using trifluoroacetic acid in dichloromethane. LC (method 2): tR=0.98 min; Mass spectrum (ESI+): m/z=330 [M+H]+.

출처 및 근거

ORD 기록
ord-a50daea6913c429e8e398e891304ae61
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927726B2

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