HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 4-(cyclopropylamino)piperidine-1-carboxylate | HCID 2769591 | — |
| Reactant | 3-Fluoro-4-oxazol-5-yl-benzoic acid | HCID 68290144 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-Cyclopropyl-3-fluoro-4-oxazol-5-yl-N-piperidin-4-yl-benzamide | HCID 68290215 | — |
Reaction Steps
The title compound is prepared from 3-fluoro-4-oxazol-5-yl-benzoic acid and 4-cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester following a procedure analogous to that described for Intermediate 1. The deprotection step is accomplished by using trifluoroacetic acid in dichloromethane. LC (method 2): tR=0.98 min; Mass spectrum (ESI+): m/z=330 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927726B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-a50daea6913c429e8e398e891304ae61 |
| Source note | uspto-grants-2015_01 |