HCID 58137276, compound → HCID 58137287, compound

Participants

Reaction Steps

(±)-Tert-butyl 7-bromo-3-(1-ethoxy-2-methyl-1-oxopropan-2-yl)-2,3-dihydrospiro[indene-1,4′-piperidine]-1′-carboxylate (152 mg, 0.317 mol) was dissolved in 20% TFA at 0° C. The mixture was stirred for 1 h at rt. The solvent was removed under reduced pressure to give (±)-ethyl 2-(7-bromo-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)-2-methylpropanoate which was used without purification (120 mg, 100%).

Provenance & Evidence