HCID 58137276, compound → HCID 58137287, compound

HRID 1424575Notes

Reaction equation

HRID 1424575 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:22]=1[C:9]1([CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)[CH2:8][CH:7]2[C:23]([CH3:30])([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25]>C(O)(C(F)(F)F)=O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:22]=1[C:9]1([CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)[CH2:8][CH:7]2[C:23]([CH3:29])([CH3:30])[C:24]([O:26][CH2:27][CH3:28])=[O:25]

Participants

3

Reactant 1

HCID 58137276HCID 58137276, compound

Product 1

HCID 58137287HCID 58137287, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

(±)-Tert-butyl 7-bromo-3-(1-ethoxy-2-methyl-1-oxopropan-2-yl)-2,3-dihydrospiro[indene-1,4′-piperidine]-1′-carboxylate (152 mg, 0.317 mol) was dissolved in 20% TFA at 0° C. The mixture was stirred for 1 h at rt. The solvent was removed under reduced pressure to give (±)-ethyl 2-(7-bromo-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)-2-methylpropanoate which was used without purification (120 mg, 100%).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-b8f48d2e623547828ba98632885e2b2f
Source dataset
uspto-grants-2015_01
Patent number
US08927715B2

Reaction notes

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