2-adamantyl Chloroformate → HCID 25065432, compound

HRID 1424613Notes

Reaction equation

HRID 1424613 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:13](=[CH:14][CH:15]=1)[C:7]1([CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)[CH2:6][CH:5]2[CH2:16][C:17]([OH:19])=[O:18].Cl[C:21]([O:23][CH:24]1[CH:31]2[CH2:32][CH:27]3[CH2:28][CH:29]([CH2:33][CH:25]1[CH2:26]3)[CH2:30]2)=[O:22]>>[CH3:1][C:2]1[CH:3]=[C:4]2[C:13](=[CH:14][CH:15]=1)[C:7]1([CH2:8][CH2:9][N:10]([C:21]([O:23][CH:24]3[CH:25]4[CH2:33][CH:29]5[CH2:28][CH:27]([CH2:32][CH:31]3[CH2:30]5)[CH2:26]4)=[O:22])[CH2:11][CH2:12]1)[CH2:6][CH:5]2[CH2:16][C:17]([OH:19])=[O:18]

Participants

3

Reactant 2

HCID 108785372-adamantyl ChloroformateHCID 581372982,3-Dihydro-5-methylspiro[1H-indene-1,4′-piperidine]-3-acetic acid

Product 1

HCID 25065432HCID 25065432, compound

Procedure

The title compound was prepared from 2-(5-methyl-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetic acid and 2-adamantyl chloroformate following a procedure analogous to that described in Example 57. LC-MS Method 1 tR=2.24 min, m/z=0.438; 1H NMR (CDCl3) δ=7.06 (m, 2H), 7.00 (s, 1H), 4.88 (s, 1H), 4.19 (t, 2H), 3.61 (m, 1H), 3.03 (m, 3H), 2.64 (dd, 1H), 2.48 (dd, 1H), 2.34 (s, 3H).

Sources & evidence

ORD record
ord-cd1b8c996b9342f282898cf065f79215
Source dataset
uspto-grants-2015_01
Patent number
US08927715B2

Reaction notes

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