Maleic Anhydride → HCID 66953879, compound

HRID 1424628Notes

Reaction equation

HRID 1424628 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([N:14]1[CH2:19][CH2:18][C:17]3([C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][NH:21][CH2:20]3)[CH2:16][CH2:15]1)=[O:13])[CH2:8]2.[C:29]1(=[O:35])[O:34][C:32](=[O:33])[CH:31]=[CH:30]1>>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([N:14]1[CH2:19][CH2:18][C:17]3([C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][N:21]([C:29](=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33])[CH2:20]3)[CH2:16][CH2:15]1)=[O:13])[CH2:8]2

Participants

3

Reactant 2

HCID 7923Maleic AnhydrideHCID 25064399N-(2-adamantyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxamide

Product 1

HCID 66953879HCID 66953879, compound

Procedure

The title compound was prepared from N-(2-adamantyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4′-piperidine]-1′-carboxamide and maleic anhydride following a procedure analogous to that described in Example 90. LC-MS Method 1 tR=1.7 min, m/z=478; 1H NMR (CDCl3) 1.60-2.20 (18H), 3.11 (m, 2H), 3.58 (s, 2H), 3.92 (br s, 4H), 4.39 (s, 2H), 5.00 (br s, 1H), 6.30-7.45 (6H).

Sources & evidence

ORD record
ord-4cb16fe5dd8342b9bbeaf83614d3c9ae
Source dataset
uspto-grants-2015_01
Patent number
US08927715B2

Reaction notes

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