Glutaric anhydride → HCID 66953464, compound

HRID 1424629Notes

Reaction equation

HRID 1424629 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([N:14]1[CH2:19][CH2:18][C:17]3([C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][NH:21][CH2:20]3)[CH2:16][CH2:15]1)=[O:13])[CH2:8]2.[C:29]1(=[O:36])[O:35][C:33](=[O:34])[CH2:32][CH2:31][CH2:30]1>>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[NH:11][C:12]([N:14]1[CH2:19][CH2:18][C:17]3([C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][N:21]([C:29](=[O:36])[CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34])[CH2:20]3)[CH2:16][CH2:15]1)=[O:13])[CH2:8]2

Participants

3

Reactant 2

HCID 7940Glutaric anhydrideHCID 25064399N-(2-adamantyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxamide

Product 1

HCID 66953464HCID 66953464, compound

Procedure

The title compound was prepared from N-(2-adamantyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4′-piperidine]-1′-carboxamide and glutaric anhydride following a procedure analogous to that described in Example 90. LC-MS Method 5 tR=2.034 min, m/z=494.3; 1H NMR (CD3OD) δ=1.52-1.69 (m, 4H), 1.79-2.04 (m, 16H), 2.41 (m, 2H), 2.62 (m, 2H), 3.16-3.27 (m, 2H), 3.86 (m, 2H), 3.98 (m, 3H), 7.15-7.39 (m, 3H), 7.41 (d, 1H).

Sources & evidence

ORD record
ord-6c7a9ce502f64489a6644a692260aab5
Source dataset
uspto-grants-2015_01
Patent number
US08927715B2

Reaction notes

Loading…