Ammonia → HCID 46231720, compound

HRID 1424642Notes

Reaction equation

HRID 1424642 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:28]=1[C:9]1([CH2:14][CH2:13][N:12]([C:15](=[O:27])[NH:16][CH:17]3[CH:24]4[CH2:25][CH:20]5[CH2:21][CH:22]([CH2:26][CH:18]3[CH2:19]5)[CH2:23]4)[CH2:11][CH2:10]1)[CH2:8][CH:7]2[CH2:29][C:30](O)=[O:31].[NH3:33]>O1CCOCC1>[NH2:33][C:30](=[O:31])[CH2:29][CH:7]1[C:6]2[C:28](=[C:2]([Br:1])[CH:3]=[CH:4][CH:5]=2)[C:9]2([CH2:10][CH2:11][N:12]([C:15]([NH:16][CH:17]3[CH:24]4[CH2:23][CH:22]5[CH2:21][CH:20]([CH2:19][CH:18]3[CH2:26]5)[CH2:25]4)=[O:27])[CH2:13][CH2:14]2)[CH2:8]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 46216689HCID 46216689, compound

Product 1

HCID 46231720HCID 46231720, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared from (±)-2-(7-bromo-1′-((2-adamantyl)carbamoyl)-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)acetic acid following a procedure analogous to that described in Example 127 except that 0.5 M NH3 in dioxane was used in place of NH3 gas.

Sources & evidence

ORD record
ord-02484162990944babd0dfc9f9f84b1ae
Source dataset
uspto-grants-2015_01
Patent number
US08927715B2

Reaction notes

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